Joliet, IL. (Oct. 19, 2016) — Today, the prestigious American Journal of Medicine (The Green Journal) published the results of the study titled, “Randomized Trial of Plaque Identifying Toothpaste: Dental Plaque and Inflammation,” which found that Plaque HD®, a plaque identifying toothpaste, significantly reduced dental plaque in the mouth and inflammation throughout the entire body.

In this study, 61 healthy subjects aged 19 to 44 years were randomized to Plaque HD® (n=31) or placebo (n=30) for 60 days. Changes from baseline to follow-up in dental plaque and hs-CRP were accessed:

Plaque HD® significantly reduced dental plaque when compared with the placebo toothpaste Plaque HD® significantly reduced hs-CRP when compared with the placebo toothpaste

Inflammation is intimately involved in the pathogenesis of atherosclerosis and is accurately measured by high sensitivity C-reactive protein (hs-CRP), a sensitive marker for cardiovascular disease. Heart attack is the No. 1 cause of death in the world and the United States, killing over 370,000 men and women each year. Stroke is the No. 5 cause of death in the United States, killing nearly 129,000 men and women each year.1

The senior author was Charles H. Hennekens, M.D., Dr.P.H., who also authored the seminal article on inflammation, aspirin and heart disease published in 1997. In addition to conducting his groundbreaking research, Dr. Hennekens is the first Sir Richard Doll professor and senior academic advisor to the dean in the Charles E. Schmidt College of Medicine at Florida Atlantic University, and the coauthors included investigators at the University of Illinois at Chicago School of Dentistry and the University of Wisconsin School of Medicine and Public Health. Last month, the prestigious New England Journal of Medicine noted that his 1997 study, “Inflammation, Aspirin, and the Risk of Cardiovascular Disease in Apparently Healthy Men,” was their most influential over the last 20 years. That original research from the landmark Physician’s Health Study, in which Dr. Hennekens was founding Principal Investigator, was the first to demonstrate that C-reactive protein, a sensitive marker of inflammation, predicted future heart attacks and strokes.

Dr. Hennekens stated, “the observed reduction in inflammation among those assigned at random to Plaque HD® supports the hypothesis of a reduction in risks of heart attacks and strokes.”

The Editor-in-Chief of the American Journal of Medicine, Joseph Alpert MD, a renowned cardiologist, took the unusual step to write an accompanying editorial: “Can a toothpaste reduce risks of heart attacks and strokes?” He opined about the relationship of oral health to heart attacks and strokes which he first learned from his father, a dentist.

Plaque HD® is the first plaque-identifying toothpaste that reveals plaque so that it can be removed with directed brushing. In addition, the product’s proprietary formulation, Targetol Technology®, contains unique combinations and concentrations of cleaning agents that weaken the core of the plaque structure to help the subject more effectively remove the plaque.

“The direct test of the hypothesis that Plaque HD® reduces risks of heart attacks and strokes requires a large scale randomized trial of sufficient size and duration designed a priori to do so,” stated Dr. Hennekens. “We are already preparing an investigator initiated research grant proposal to the United States National Institutes of Health (NIH) with coauthor Patrick McBride, MD, MPH, Professor of Medicine and Senior Associate Dean at the University of Wisconsin School of Medicine and Public Health as Principal Investigator.”

Dr. Hennekens added, “this trial is important and timely because a positive finding would have enormous clinical and public health implications.”

ABOUT Plaque HD®: Plaque HD® is the first professional plaque-identifying toothpaste. Plaque HD® uses Targetol® Technology to highlight the plaque missed while brushing, giving you that fresh-from-the-dentist feeling every day. With regular brushing, the 1-step, easy-to-use Plaque HD® formula fights cavities, freshens breath, and helps prevent gum disease. By brushing daily with Plaque HD® toothpaste, in addition to improving your oral hygiene, you are also enhancing the health of your entire body since plaque in the mouth is closely linked to many systemic diseases, such as heart disease and stroke.

1American Heart Association “Heart Disease, Stroke and Research Statistics At-a-Glance.” Available online at:

Last accessed on October 7, 2016

Plaque HD® Plaque Identifying Toothpaste
Plaque HD® Remineralizing Mouth Rinse
Maximum Oral Health

Plaque HD® Remineralizing Mouth Rinse

Plaque HD Health Defined

  • Whitening mouth rinse
  • Remineralizing
  • Non alcohol
  • No artificial sweetners
  • Natural essential oils and Aloe for soothing refreshing feel
  • No fluoride
  • No propylene glycols
  • No sodium lauryl sulfate (SLS)

Oral Health Benefits:

  • Kills Germs That Cause Bad Breath
  • Long Lasting Fresh Breath
  • Gently Whitens Teeth without harsh chemicals
  • With Baking Soda, to actively Neutralize Acids
  • & Natural Whitening action
  • Rich in Minerals That Restore Enamel
  • With Xylitol, Natural Sweetener with beneficial minerals for the enamel
  • With Zinc Citrate to Freshen Breath & help reduce Plaque
  • With Natural Mints & Tea Tree Oil complex for a natural cleansing action
  • With Natural Essential Oils & Aloe extracts to help in refreshing mouth and aid in reducing oral cavity bacteria naturally
  • Proudly Made In USA

    The combination of unique essential oils with both antiseptic and antibacterial properties help reduce bacteria and inflammation naturally in the oral cavity.
    The presence of Baking Soda has a natural buffering action to neutralize acids and at the same time help fight stains naturally without the use of harsh chemicals and whitening agents.
    Xylitol is a great natural alternative to artificial sweeteners and is also proven to show possible effective strengthening properties when used in conjunction with other Mineralizing agents.
    Avocado oils and other fruit extracted oils natural soothe help to rehydrate both gums and oral tissue.


Plaque HD® is the first professional plaque-identifying toothpaste.
Targetol Technology® lets you see the plaque that you may have missed while brushing, for that fresh-from-the-dentist feel everyday.


TARGETOL TECHNOLOGY® contains disclosing agents to color and identify plaque build-up on teeth. This allows the patient to target any areas of plaque build-up that may have been missed during brushing to completely remove plaque from teeth.
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Plaque HD® in the media. See more »

PlaqueHD® Partners with Humble Smile Foundation

Teaching kids in Mozambique, Africa how to remove plaque and keep their gums healthy




PlaqueHD® Partners with Humble Smile Foundation

Teaching kids in Mozambique, Africa how to remove plaque and keep their gums healthy

PLAQUE HD®, the innovative fluoridated toothpaste with TARGETOL TECHNOLOGY®, was chosen by Humble Smile Foundation to be the toothpaste of choice for its oral health promotion projects. PLAQUE HD® contains disclosing agents to color and identify plaque build-up on teeth, allowing the brusher to target any areas of plaque build-up that may have been missed during brushing. President of the Humble Smile Foundation, Dr. Darren Weiss states: "The aim of our outreach work is to instill healthy behavioral habits at a young age so that these healthy oral hygiene and nutritional habits will stick with them for life. PLAQUE HD® is the perfect product to coach underprivileged children who have never seen a dentist or held a toothbrush before. It's easy for them to understand that they must brush all the stained plaque
away, and they will learn to brush effectively and for an adequate amount of time. Preventing oral disease for these kids is imperative because they have no access to dental treatment."

Humble Smile Foundation promotes oral health initiatives in schools in those areas around the world where unmet needs are great. That means places where at least 8 out of ten children suffer from tooth decay, but have no way to treat the cavities in their teeth because dentistry is unavailable to them.

We at Plaque HD® are thrilled at the thought of our technology being used on the front lines, where the impact on oral disease and people’s lives will be immense. Poor oral
health not only results in cavities and gum disease, but also increases the risk of many systemic diseases such as cardiovascular disease and stroke.

It is a privilege being part of Humble Smile Foundation's important work to help improve peoples’ oral health and overall well-being.

Our first collaboration with the Humble Smile Foundation will be on the Sunshine & Smiles project in Mozambique in September 2016, together with partners - Sunshine Approach Foundation and the International Association of Dental Students. PLAQUE HD® has donated 1300 tubes of PLAQUE HD® toothpaste to help school children in Matola and Manjacaze develop thorough tooth brushing habits as part of a comprehensive preventive program. We at PLAQUE HD® look forward to collaborating with Humble Smile Foundation on many projects in the future, both locally and abroad.



If you like your Teeth and Want them Clean, ORDER THIS NOW!!!

By David J. Schneid on September 10, 2015

I tried this product and can say without hesitation it is fantastic. This toothpaste makes sure you do a quality cleaning each and every time you brush. The great taste is a bonus. I cannot recommend this product any stronger. If you want to make sure you are doing the best job brushing your teeth, you need to get this product.
Additionally, this product arrived in a box in great shape and was in the perfect condition upon arrival. I will be ordering it again.


By Pig Pen on August 27, 2015

It actually works! The hygienist has always criticized my teeth, telling me I need to floss more, need to brush in hard-to-reach places. For Pete's sake, who has time to spend 30 minutes twice a day flossing, brushing and rinsing. My recent dental cleaning was truly pleasant and attribute that to this paste. Not only does it taste great, but it helps keep my teeth cleaner.

Plaque HD® is a winner!

By JERRY LEWIN on September 19, 2015

This product far exceeded my expectations. After using Plaque HD® for a couple of days I have already noticed a reduction in the plaque it helped to identify. It continues to train you to focus on the areas you might be missing with other toothpastes. I also love the fresh mint taste it leaves in your mouth. The family has also begun to use the product so ordering more product is imminent. Thank you Plaque HD®!

New favorite toothpaste!

By Inga Vaziri on November 13, 2015

I must share with the world how AMAZING this toothpaste is! It shows where the plaque is and helps to remove plaque and stains on the teeth just by brushing it - how amazing is that ! I don't need to use any other product to make my teeth and gums healthy - this toothpaste covers everything!
My kids love it too! I highly recommend this product!

This toothpaste is AMAZING!!!!

By Sonia B.on November 2, 2015

I have been using it for over a week, and I can see a big difference. Sooooo love the way it makes my teeth feel and the way it targets the area with plaque. I will be ordering more for sure and I would definitely recommend it. Go ahead order it, you won't be disappointed!

This toothpaste has forced me to brush better! I highly recommend it

By Ildiko Meltzeron September 13, 2015

As an adult who wore braces, I was skeptical about this toothpaste at first. After one week of use, I am a convert. It is humbling to see how much plaque was left behind with my vigorous brushing. This toothpaste has forced me to brush better! I highly recommend it.

I was not disappointed! After only using Plaque HD®for a week

By Ella Millenon September 10, 2015

I decided to try this based on a recommendation of a friend. I was not disappointed! After only using Plaque HD® for a week, I already notice an improvement in the feel and appearance of my teeth and gums. Don't let the price deter you, it is money well spent! I will definitely be ordering more Plaque HD® for my children to use as well!

Love this product

By Scott A. Lavinon September 9, 2015

Love this product! It really works. Never saw anything like this before so I was really curious to see it in action and it delivered. I have three young boys and it has incentivized them to brush better and more carefully. Would definitely recommend.

Win - Win

By Briana M. Landinoon September 1, 2015

I can't decide if I am happy or sad to be seeing all the areas I was missing, but at least now I can be sure to pay extra attention to those areas. The mint flavor is great, and since I already

Wow, where was this when I was growing up.

By Jerome Gralewski on September 9, 2015

I recently went on Google to look up something that could help remove Plaque on my daughter teeth, and I came across Plaque HD®. After purchasing this product, I feel like it has changed the way my daughter brushes her teeth. The color definitely sticks out on the sections of her teeth where she needs to spend a little more time. The flavor is great and at the end of the day I feel confident that she will brush better seeing as she can now actually see the color that is left on here teeth where the plaque may be. She has already asked if she could try the Mint flavor. We will definitely become a repeat customer.

Awesome product. I wish they had this when I...

By Anthony Landino on September 13, 2015

Awesome product. I wish they had this when I was a kid. It would have saved me a lot of trips to the dentist. I thought I was brushing thoroughly with an electric toothbrush but Plaque HD® showed me the spots I was missing. I highly recommend this product for children and adults.

Not Just For Kids!

By Michael on September 12, 2015

We bought this toothpaste hoping it would encourage our kids to brush better and the results have been awesome! Not only did it identify places that they needed to brush better but they loved the taste and have been brushing longer. My wife and I tried it out and we both agreed; we wish we had found this toothpaste a long time ago!

brush better. Tastes as good as any toothpaste I've ever ...

By Martin Friend on September 30, 2015

It's actually hard to believe it, but this toothpaste does what the maker says it is going to do. Until you see it, it is hard to believe. It has definitely helped our family - and especially my pre-teen, brush better. Tastes as good as any toothpaste I've ever used as well. Definitely will be buying more.

Five Stars

By Eric on September 10, 2015

This Toothpaste is awesome!

Great tasting, and makes brushing teeth fun for kids!

By JYung on February 11, 2016

My 2 and 3 year olds LOVE this toothpaste! Before I could not get them to brush their teeth. Now I cannot get them to stop! The coloring helps us figure out where they missed and where they need to go over again. It tastes great, too! As a mom who is very worried about food chemicals in food and products, I am fine with the ingredients in this toothpaste. The whole family loves this toothpaste, and I would not hesitate to buy this product again. There is nothing else like this on the market, I cannot understand why they have not thought of this sooner!

Amazing what plaque HD® does

By Kelly Lewison on February 9, 2016

I could not get my kids to brush their teeth. It was a fight every night. Not onlydoes this toothpaste taste good, they love how it turns the plaque blue. Even my 17 year old likes it. I ordered bubble berry my kids are brushing 2 times a day and the blue is helping them see the plaque and brush it off. I love this stuff it's well worth the price & it cleans off of the counters and sink easy. Whoever invented this is a genius! I will definitely but this again.

Plaque HD® Toothpaste is Worth Every Penny

By Lesley Allen on February 8, 2016

Amazing product! It works really well and I can't believe how even as an adult it's helping me do a better job brushing. It doesn't make a mess like the red tablets and is easy to use. The kids like using it and for braces it is really showing them where they need to brush. Wish they'd had this when I had braces! Highly recommend for everyone in the family. Your dentist will be impressed by how clean your teeth are after using this toothpaste. A pea sized amount is all you need so the tube lasts longer than other kinds. Worth every penny.

Great at identifying problem brushing areas

By Amazon Customer on January 31, 2016

Does a great job of identifying problem brushing areas. Will purchase again

Shipping and handling was easy and my teeth are whiter than before

By Amazon Customer on January 27, 2016

This anti-cavitiy toothpaste blew my mind, my recent experience with the new tagetol technolgy takes this toothpaste to the next level and makes it worth its price. Shipping and handling was easy and my teeth are whiter than before, plaque free and the mint flavor tastes very fresh. Simply follow the instructions, it is quite easy to identify the green plaque build up - once identified in the mirror, all you need to do is brush it off!

This product is absolutely amazing! The coloring helps my "clean freak" self make ...

By Amazon Customer on January 27, 2016

This product is absolutely amazing! The coloring helps my "clean freak" self make sure that I brush my teeth thoroughly! I also love the fresh taste it leaves

Five Stars

By Suzanne Searleson on January 26, 2016

Excellent product! Cleans thoroughly, eliminates plaque and leaves a fresh taste. Highly recommend this product


PlaqueHD® Partners with
Dolphin Imaging & Management Solutions